鞠婧祎

尹磊

个人信息Personal Information

副教授

性别:男(nan)

毕业院校(xiao):吉林大学

学(xue)位:博士

所(suo)在单位(wei):生命科学(xue)与药学(xue)学(xue)院

电子邮箱(xiang):leiyin@liviaday.com

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个人简介Personal Profile

尹磊(lei),大连理工大学(xue)生(sheng)命科(ke)学(xue)与药(yao)学(xue)学(xue)院副(fu)教授,吉林(lin)(lin)大学(xue)药(yao)理学(xue)博(bo)士,药(yao)物(wu)分(fen)析(xi)学(xue)硕士,制药(yao)工程(cheng)学(xue)士,美国(guo)亚(ya)利桑(sang)那大学(xue)药(yao)学(xue)博(bo)士后,中国(guo)分(fen)析(xi)药(yao)理学(xue)委(wei)员(yuan)会(hui)青年委(wei)员(yuan),中国(guo)药(yao)理学(xue)会(hui)会(hui)员(yuan),通(tong)化市抗击新冠疫情及(ji)核酸(suan)检(jian)测荣誉市民,吉林(lin)(lin)省优秀青年人才(cai)基(ji)金获(huo)得者。Biomedicine & PharmacotherapyCurrent Analytical Chemistry等(deng)SCI杂(za)志审稿人,主(zhu)要(yao)从事小分子药物(wu)(wu)、多肽(tai)蛋(dan)白(bai)类(lei)药物(wu)(wu)、PEG修饰纳米制(zhi)剂、高分子聚合物及药(yao)(yao)(yao)用(yong)辅料的精准分析(xi)(xi)及药(yao)(yao)(yao)物代谢动力(li)学研究、非靶(ba)(ba)向(xiang)及靶(ba)(ba)向(xiang)性代谢组学研究、临(lin)床血(xue)药(yao)(yao)(yao)浓度监(jian)测、食(shi)品及环境农药(yao)(yao)(yao)残(can)留分析(xi)(xi)等。熟悉小分子药(yao)(yao)(yao)物、蛋白多(duo)肽类药(yao)(yao)(yao)物、高分子聚合物的一维液相色(se)谱(pu)串(chuan)联质(zhi)谱(pu)方(fang)(fang)法及二(er)维液相色(se)谱(pu)串(chuan)联质(zhi)谱(pu)方(fang)(fang)法的开发,迄(qi)今共建立了体内药(yao)(yao)(yao)物浓度分析(xi)(xi)新(xin)方(fang)(fang)法100余项(xiang),在Talanta, Analyst, Analytical and Bioanalytical Chemistry, BiomacromoleculesJournal of Pharmaceutical and Biomedical Analysis, Journal of Pharmaceutical Analysis, Journal of Pharmacy and Pharmacology, Journal of Chromatography B, Acta Pharmaceutica Sinica B, Journal of Separation Science, Chromatographia, Analytical Methods, Journal of Chromatographic Science, Clinical Drug Investigation,International Journal of Pharmaceutics等国际主(zhu)流杂志发表SCI论文30余篇,申请(qing)发明专利5项,近十年来,主持国家自(zi)然科学(xue)基金青年基金1项,吉林省优秀青年人才(cai)基金1项,中央(yang)高校基本科(ke)研业(ye)务费资助(zhu)引进人才科(ke)研专题1项(xiang),参与国家自然(ran)科学基金重点项(xiang)目2项(xiang),面上项(xiang)目4项,国家科技(ji)重大专(zhuan)项1项。

作(zuo)为负责人主持科(ke)技项目包括:

1)国家自然科(ke)学基金(jin)青(qing)年基金(jin)项目:基于CID In-Quadrupole 的阿霉(mei)素及多尺度(du)PEG化(hua)阿霉素(su)比较药代动力学研究(编(bian)号:81603182,执行年(nian)限:2017/01-2019/12)。

2)吉(ji)林省优秀青(qing)年人(ren)才基金项目(mu):基于LC-SWATH技术(shu)的PEG修饰多柔比(bi)星纳米(mi)胶束体内(nei)多形态成分的(de)精准分析(xi)(编号:20190103082JH,执行(xing)年限:2019/01-2020/12)。

3)中(zhong)央高校基本(ben)科研(yan)业务费资助引进人才科研(yan)专题(ti):基于(yu)质谱(pu)技术的纳米制剂药代动(dong)力学研(yan)究(编号(hao):DUT21RC(3)057,执行年限:2021/06-2022/12)。

以主(zhu)要参与人参加科(ke)技项目包括:

1)国家(jia)自然(ran)科学基金重(zhong)点项(xiang)目: 药物(wu)载体(ti)递送(song)系统体(ti)内时空命(ming)运(yun)研究,(编号(hao):82030107,执行年限2021-01至(zhi)2025-12)。

2)国家自然科学基金重点项(xiang)目:桥接细胞与整(zheng)体的纳米药代(dai)动力学研究(jiu)(编号:81430087,执行年限:2015/01-2019/12)。

3)国家科技(ji)重大专项:药(yao)物一致性评(ping)价关键技(ji)术(shu)与标(biao)准研究(编号:2017ZX091010012017/07-2020/07)。

4)国家自然科学(xue)基金面(mian)上项目: 基于(yu)质谱新技(ji)术的PEG-PLA紫(zi)杉醇纳米(mi)胶束体内多形(xing)态成(cheng)分的精准分析(xi)(编号:81872831,执行(xing)年(nian)限(xian):2019/01-2022/12)

5)国家自然科学基(ji)金(jin)面上项目(mu): 基于连续可变窗口(kou)采集技(ji)术的泊(bo)洛沙(sha)姆聚合物LC-HR-MS/MS 分析方法研究与应用(yong)(编号:81773692,执行年限:2018/01-2021/12)

6)国家自然(ran)科学基(ji)金面上项目: 新型硒(xi)类化合物对晚期前列(lie)腺(xian)癌的治(zhi)疗作(zuo)用及其分(fen)子机制的研究 (编号:81272851,执行年限:2014/01-2017/12)

7)国家自(zi)然科学基金面上项目:几种药物分子的晶型设计构(gou)筑及其构(gou)动关系(编(bian)号:21371024,执行年限(xian):2013/11-2017/12)。

参与横向课题(负责分析方法开发、生(sheng)物(wu)样品测(ce)试(shi)、数据处理):

原人参二(er)醇人体(ti)(ti)药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究;头孢替坦二(er)钠人体(ti)(ti)药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究;落新妇苷大鼠药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究;苦碟子注射液(ye)比(bi)格犬(quan)(quan)药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究;灯盏花(hua)乙素人体(ti)(ti)药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究,异丙(bing)肌酐(gan)片人体(ti)(ti)药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究;卡(ka)前(qian)列(lie)腺素甲酯比(bi)格犬(quan)(quan)药(yao)(yao)代(dai)(dai)(dai)动(dong)力(li)(li)学(xue)研(yan)(yan)究;前(qian)列(lie)腺素E1比(bi)格犬(quan)药(yao)(yao)代动力(li)学研究;抗癫(dian)痫(xian)药(yao)(yao)临床(chuang)血药(yao)(yao)浓(nong)度监(jian)测液相(xiang)色(se)谱串(chuan)联(lian)质谱检测试剂(ji)(ji)盒(he)的(de)研发;甲(jia)氨喋呤临床(chuang)血药(yao)(yao)浓(nong)度监(jian)测液相(xiang)色(se)谱串(chuan)联(lian)质谱检测试剂(ji)(ji)盒(he)的(de)研发;激素血药(yao)(yao)浓(nong)度监(jian)测液相(xiang)色(se)谱串(chuan)联(lian)质谱检测试剂(ji)(ji)盒(he)的(de)研发;维生素ADEK血药浓度监测液相色谱串(chuan)联质(zhi)谱检测试剂盒(he)的研发

510篇代表性论文:

论文1Yin Lei, Ren Tianming, Zhao Shiying, Shi Meiyun*, Gu Jingkai*. Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique, Talanta, 2020.01, 206:120184.

论文2Yin Lei, Feng Yixuan, Tong Jin, Guo Zhiqiong, Zhang Yuyao, Zhang Qi, Sun Yantong, Fawcett JP, Gu Jingkai*. Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study, Anal Bioanal Chem, 2019.08, 411(20):5139-5148

论文(wen)3Lei Yin, Zhi Zhang, Yingze Liu, Yin Gao*, Jingkai Gu*. Recent advances in single-cell analysis by mass spectrometry, Analyst, 2019.02,144(3):824-845.     

论文4Wenhai Lin#, Lei Yin#, Tingting Sun, Tingting Wang, Zhigang Xie*, Jingkai Gu*, Xiabin Jing. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules, 2018.05, 19(5):1625-1634.(并列一(yi)作)

论文(wen)5Yin Lei, Su Chong, Ren Tianming, Meng Xiangjun, Shi Meiyun, Paul Fawcett J, Zhang Mengliang, Hu Wei, Gu Jingkai*. MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra, Analyst, 2017.11, 142(22):4279-4288.

论文6Shi Meiyun, Zhao Xiaojun, Wang Tingting, Yin Lei*, Li Yanyan, A LC-MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma, J Chromatogr Sci, 2018.10, 56(9):828-834通讯作者(zhe)

论(lun)文7Lei Yin, Meiyun Shi, Tingting Wang, Miaomin Zhang, Xiaojun Zhao, Ying Zhang, Jingkai Gu*, A Parallel-Column LC–MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring, Chromatographia, 2017.01,80:137-143.

论文8Lei Yin, Junfeng Yang, Xiangjun Meng, Bo Yang, Chong Su, Zhichao Yang, Mi Zheng, Limei Zhao, Jingkai Gu* and Guijie Xin*, An LC-MS/MS method to determine PABA and DIP, Analytical Methods, 2016.01, 8:1013-1020.

论文9Lei Yin#, Tingting Wang#,Meiyun Shi#,Ying Zhang, Xiaojun Zhao, Yan Yang*, Jingkai Gu*, Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring, J. Sep. Sci. 2016.03, 39(5):964-72.

论文10Meiyun Shi, Mengyao Xu, Lei Yin*. Pharmacokinetic, Bioavailability and Tissue Distribution Study of Astilbin in Rats, Journal of Pharmacy and Pharmacology, 2020.08,72(8):1061-1071.通讯作者

申请专利具体(ti)如下:

1. 一种生物样本中PEG 化药物的定(ding)量测定(ding)方法,ZL 201610031386.1

2. 一种生物样本中PEG 含量的测定(ding)方法,ZL 201510356323.9

3. 一种PEGPEG化药物的分析检测方法及其(qi)应用(ZL 201710706546.2

4. 一种(zhong)定量测定生物(wu)样品中前列腺素的(de)方法(ZL 201710707523.3)

5. 一种脑靶(ba)向艾司利卡西平酯类前(qian)药及(ji)其应(ying)用(ZL201611039363.1)

 


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