红色娘子军

尹磊

个人信息Personal Information

副教授

硕士生导师

性别:男

毕业(ye)院校:吉林大学(xue)

学位:博士

所在单位:生(sheng)命(ming)科(ke)学(xue)与药学(xue)学(xue)院

办公地点:F03-409

联系方(fang)式:leiyin@liviaday.com

电(dian)子邮箱:leiyin@liviaday.com

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个人简介Personal Profile

尹磊,药(yao)(yao)学(xue)(xue)(xue)(xue)副教(jiao)授(shou),美国(guo)亚利桑那大学(xue)(xue)(xue)(xue)药(yao)(yao)学(xue)(xue)(xue)(xue)博(bo)士(shi)(shi)后,吉(ji)林(lin)大学(xue)(xue)(xue)(xue)药(yao)(yao)理学(xue)(xue)(xue)(xue)博(bo)士(shi)(shi),药(yao)(yao)物分(fen)析(xi)(xi)学(xue)(xue)(xue)(xue)硕士(shi)(shi),制药(yao)(yao)工(gong)程学(xue)(xue)(xue)(xue)士(shi)(shi),中(zhong)国(guo)分(fen)析(xi)(xi)药(yao)(yao)理学(xue)(xue)(xue)(xue)委员会(hui)青(qing)年(nian)委员,中(zhong)国(guo)药(yao)(yao)理学(xue)(xue)(xue)(xue)会(hui)会(hui)员,通化市(shi)抗(kang)击新(xin)冠疫(yi)情(qing)及核(he)酸检测荣(rong)誉市(shi)民,吉(ji)林(lin)省优(you)秀(xiu)青(qing)年(nian)人才基金获(huo)得者。Biomedicine & PharmacotherapyCurrent Analytical ChemistrySCI杂志(zhi)审稿人,主要(yao)从事(shi)小分子药(yao)物、多肽蛋白类药(yao)物、PEG修饰纳米制(zhi)剂、高分子聚(ju)合物(wu)及药(yao)(yao)(yao)用辅料(liao)的(de)精(jing)准分析及药(yao)(yao)(yao)物(wu)代谢动力学(xue)研究(jiu)、非(fei)靶向及靶向性代谢组学(xue)研究(jiu)、临床(chuang)血药(yao)(yao)(yao)浓(nong)度监(jian)测、食品及环境(jing)农药(yao)(yao)(yao)残留(liu)分析等(deng)。熟悉(xi)小(xiao)分子药(yao)(yao)(yao)物(wu)、蛋白多肽(tai)类药(yao)(yao)(yao)物(wu)、高分子聚(ju)合物(wu)的(de)一维液相色(se)谱(pu)串(chuan)联质谱(pu)方法(fa)(fa)及二(er)维液相色(se)谱(pu)串(chuan)联质谱(pu)方法(fa)(fa)的(de)开发,迄今共(gong)建立了体内药(yao)(yao)(yao)物(wu)浓(nong)度分析新方法(fa)(fa)100余项,在Talanta, Analyst, Analytical and Bioanalytical Chemistry, BiomacromoleculesJournal of Pharmaceutical and Biomedical Analysis, Journal of Pharmaceutical Analysis, Journal of Pharmacy and Pharmacology, Journal of Chromatography B, Acta Pharmaceutica Sinica B, Journal of Separation Science, Chromatographia, Analytical Methods, Journal of Chromatographic Science, Clinical Drug Investigation,International Journal of Pharmaceutics等国际主流杂志发表(biao)SCI论文30余(yu)篇,申请发明专利(li)5项,近十年来,主(zhu)持(chi)国家自(zi)然科(ke)学基金(jin)青年基金(jin)1项(xiang),吉林省优秀青年人(ren)才基金(jin)1项(xiang),中央高校基(ji)本科研业务(wu)费资助引进人才科研专题(ti)1项,参与国家自然(ran)科学基金(jin)重点项目(mu)2项,面上项目4项,国家(jia)科技重大专项1项。

作为负责(ze)人主持(chi)科技项目(mu)包括(kuo):

1)国家自然科学(xue)基(ji)金青(qing)年基(ji)金项目(mu):基(ji)于CID In-Quadrupole 的阿霉素及多(duo)尺(chi)度(du)PEG化阿霉素比较药代动力学研究(jiu)(编号:81603182,执行年限:2017/01-2019/12)。

2)吉林省优秀青年(nian)人才基金项目:基于(yu)LC-SWATH技术的PEG修饰多柔比星纳米(mi)胶束体(ti)(ti)内多形态(tai)成分(fen)的精(jing)准分(fen)析(编(bian)号:20190103082JH,执行(xing)年限:2019/01-2020/12)。

3)中央高校基(ji)本科研业务费资助引进人才科研专题:基(ji)于质谱技术的纳(na)米制剂药代动力学研究(编号:DUT21RC(3)057,执行年限:2021/06-2022/12)。

以主(zhu)要(yao)参(can)与人参(can)加科技项目包括(kuo):

1)国家自然(ran)科学(xue)基金重点项目: 药(yao)物载体递送系统(tong)体内(nei)时空命(ming)运(yun)研究(编号:82030107,执行年限2021-012025-12)。

2)国家自然科学基金重(zhong)点项(xiang)目:桥(qiao)接(jie)细胞与(yu)整体的纳米药代动力(li)学研究(编号(hao):81430087,执行年限:2015/01-2019/12)。

3)国家科技(ji)重(zhong)大(da)专项(xiang):药(yao)物(wu)一致性评价关键技(ji)术与标准研究(编(bian)号:2017ZX091010012017/07-2020/07)。

4)国家(jia)自(zi)然(ran)科学基金面(mian)上(shang)项目: 基(ji)于质(zhi)谱新技术的PEG-PLA紫(zi)杉醇纳米胶束(shu)体内多形(xing)态成分(fen)的精(jing)准分(fen)析(编号:81872831,执行(xing)年限:2019/01-2022/12)

5)国家自然(ran)科学基金面(mian)上项目(mu): 基于连(lian)续可变窗口采集技术的泊洛(luo)沙姆聚合物(wu)LC-HR-MS/MS 分析方(fang)法研(yan)究与应用(编号:81773692,执行年限(xian):2018/01-2021/12)

6)国家自然科(ke)学(xue)基金(jin)面(mian)上项目: 新型(xing)硒类化(hua)合物对晚期前(qian)列腺癌的(de)治(zhi)疗作用及其分子机制的(de)研究 (编号:81272851,执行年限:2014/01-2017/12)

7)国家(jia)自然科学(xue)基金面上(shang)项目:几种药物(wu)分子的(de)晶型设计构(gou)筑及其构(gou)动关系(编号(hao):21371024,执行年限:2013/11-2017/12)。

参与横向课题(负责分析方法(fa)开发(fa)、生(sheng)物样品(pin)测试、数(shu)据处(chu)理(li)):

原人(ren)参二醇人(ren)体(ti)(ti)(ti)药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu);头孢替坦(tan)二钠人(ren)体(ti)(ti)(ti)药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu);落新(xin)妇苷大鼠药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu);苦(ku)碟子注射液比(bi)格犬药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu);灯盏花乙素人(ren)体(ti)(ti)(ti)药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu),异丙肌(ji)酐片人(ren)体(ti)(ti)(ti)药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu);卡前(qian)列腺素甲酯比(bi)格犬药(yao)(yao)代(dai)(dai)动(dong)力学(xue)(xue)研究(jiu);前(qian)列腺素E1比格(ge)犬药代(dai)动力学研究;抗癫痫(xian)药临(lin)(lin)床血(xue)药浓(nong)度监测(ce)液相(xiang)色(se)谱(pu)串联(lian)(lian)质谱(pu)检(jian)(jian)测(ce)试剂(ji)盒的研发(fa);甲氨喋呤临(lin)(lin)床血(xue)药浓(nong)度监测(ce)液相(xiang)色(se)谱(pu)串联(lian)(lian)质谱(pu)检(jian)(jian)测(ce)试剂(ji)盒的研发(fa);激素血(xue)药浓(nong)度监测(ce)液相(xiang)色(se)谱(pu)串联(lian)(lian)质谱(pu)检(jian)(jian)测(ce)试剂(ji)盒的研发(fa);维生素ADEK血药浓(nong)度监(jian)测液相色谱串(chuan)联质(zhi)谱检测试剂盒的研发

第一(yi)作者/通讯作(zuo)者代表性论文:

论文1: Comparison of LC-MS3 and LC-MRM strategy for quantification of methotrexate in human plasma and its application in therapeutic drug monitoring, J Pharm Biomed Anal. 2021, 205:114345.第一作者

论文2: A LC-MS3 strategy to determine lamotrigine by Q-Q-trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity, Anal Methods. 2021, 13(38):4478-4484. 通讯作者

论文3: Development and validation of a liquid chromatography-tandem mass spectrometry method with triple-stage fragmentation to determine levetiracetam in epileptic patient serum and its application in therapeutic drug monitoring. J Sep Sci. 2021 Oct 14. doi: 10.1002/jssc.202100639. 并列第一作者

论文4: Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique, Talanta, 2020.01, 206:120184. 第一(yi)作者

论文(wen)5: Pharmacokinetic, Bioavailability and Tissue Distribution Study of Astilbin in Rats, Journal of Pharmacy and Pharmacology, 2020.08,72(8):1061-1071. 通(tong)讯作(zuo)者

论(lun)文6: Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study, Anal Bioanal Chem, 2019.08, 411(20):5139-5148. 第一作(zuo)者(zhe)

论文7: Recent advances in single-cell analysis by mass spectrometry, Analyst, 2019.02,144(3):824-845.  第一作者  

论(lun)文8: The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules, 2018.05, 19(5):1625-1634. 并列第一作者

论(lun)文9: MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra, Analyst, 2017.11, 142(22):4279-4288. 第(di)一作(zuo)者

论文10: A LC-MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma, J Chromatogr Sci, 2018.10, 56(9):828-834. 通讯作(zuo)者

论文11: A Parallel-Column LC-MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring, Chromatographia, 2017.01,80:137-143. 第(di)一作者

论文12: An LC-MS/MS method to determine PABA and DIP, Analytical Methods, 2016.01, 8:1013-1020. 第一作者

论(lun)文13Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring, J. Sep. Sci. 2016.03, 39(5):964-72. 并列第一作者

论文14Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 998-999:8-14. 第(di)一作者

论文15: A liquid chromatography-tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2013, 931:12-6. 第一作者

论(lun)文(wen)16: Rapid quantification of astilbin in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study. Chemical Research in Chinese Universities.2013, 29, 1078–1082. 第一作者

申请专利具体如下:

1. 一种生物样(yang)本中(zhong)PEG 化药物的定量测定方法,ZL 201610031386.1

2. 一种生物样本中PEG 含量的测(ce)定方法,ZL 201510356323.9

3. 一种PEG及(ji)PEG化药物的分析检测方法(fa)及(ji)其应用(ZL 201710706546.2

4. 一种(zhong)定量测(ce)定生物(wu)样品中前列腺素的方法(ZL 201710707523.3)

5. 一种脑靶向艾(ai)司利卡西平酯类(lei)前药及(ji)其(qi)应用(ZL201611039363.1)


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